Longevity Papers

Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis.

Bing Liang, Xiongbin Chen, Min Li ... · Mesenchymal Stem Cells · Basic Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. · pubmed

Liuwei Dihuang pill (LWDH) has been used to treat postmenopausal osteoporosis (PMOP).

Longevity Relevance Analysis (3)

The paper investigates the effects of Liuwei Dihuang pills on bone loss associated with menopause, focusing on the senescence of bone marrow mesenchymal stem cells. While it addresses a condition related to aging (postmenopausal osteoporosis), it primarily deals with symptom management rather than targeting the underlying mechanisms of aging itself. The findings may contribute to the understanding of age-related bone loss but do not significantly advance the broader field of longevity research or lifespan extension. Thus, the impact is rated as a solid but limited contribution.

Probiotics Attenuate Myopathic Changes in Aging Rats via Activation of the Myogenic Stellate Cells.

Nehal H M Abdel-Halim, Eman A E Farrag, Maha O Hammad ... · Probiotics · Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt. · pubmed

Aging represents a complex biological process associated with decline in skeletal muscle functions. Aging impairs satellite cells that serve as muscle progenitor cells. Probiotic supplementation may have many beneficial effects via various mechanisms. We examined the possible eff...

Aging represents a complex biological process associated with decline in skeletal muscle functions. Aging impairs satellite cells that serve as muscle progenitor cells. Probiotic supplementation may have many beneficial effects via various mechanisms. We examined the possible effects of probiotics in stimulating the proliferation of myogenic stellate cells in aging rats. Twenty-four male albino Sprague-Dawley rats were classified equally into four groups: adult control, old control, adult + probiotics, and old + probiotics. Probiotics (Lactobacillus LB) were administered gavage at a dose of 1 ml (1 × 10

Longevity Relevance Analysis (3)

Probiotics can stimulate the proliferation of myogenic stellate cells in aging rats. This research addresses a potential mechanism to mitigate age-related decline in muscle function, which is a significant aspect of the aging process.

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.

Catalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya ... · Antioxidants · Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. · pubmed

Increased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characterised by its association with a variety of adverse events in the older persons. The me...

Increased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characterised by its association with a variety of adverse events in the older persons. The mechanisms involved in the development of age-related chronic diseases are largely unknown; however, altered redox homeostasis due to ageing is one of the main theories. In this context, the present review explores the development and interaction between different age-related diseases, mainly linked by oxidative stress. In addition, drug interactions in the treatment of various diseases are described, emphasising that the holistic management of older people and their pathologies should prevail over the individual treatment of each condition.

Longevity Relevance Analysis (3)

The paper addresses the issue of polypharmacy in older adults, linking it to oxidative stress and age-related diseases. While it explores mechanisms related to aging and suggests a holistic approach to treatment, it primarily focuses on managing symptoms rather than addressing the root causes of aging itself. Therefore, while it contributes to the understanding of aging-related health issues, its impact on the field of longevity research is limited.