Longevity Papers

The BET inhibitor JQ1 targets fat metabolism and counteracts obesity.

Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi ... · Azepines · Department of Clinical and Biological Sciences, University of Torino, Turin, Italy. · pubmed

Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical dis...

Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. Total fat mass frequently increases during aging, often coexisting with sarcopenia, thus resulting in an emerging condition defined sarcopenic obesity (SO). Our previous data demonstrated the relevant role of the bromo and extra-terminal domain (BET) proteins inhibitor JQ1 in attenuating inflammation and fibrosis in sarcopenic mice. Moreover, we preliminarily observed that JQ1 administration markedly reduces white adipose tissue mass, suggesting a potential role of BET proteins on visceral fat deposition during aging.

Longevity Relevance Analysis (3)

The paper claims that the BET inhibitor JQ1 reduces white adipose tissue mass and may influence fat metabolism in the context of obesity. This research is relevant as it addresses the interplay between fat metabolism and aging-related conditions, specifically sarcopenic obesity, which is a significant concern in longevity research.

Naturalistic assessments in virtual reality and in real life help resolve the age-prospective memory paradox.

Nathan S Rose, Joseph M Saito · Memory, Episodic · Department of Psychology, University of Notre Dame, Notre Dame, IN, USA. · pubmed

Cognitive aging researchers have long reported "paradoxical" age differences in prospective memory (PM), with age deficits in laboratory settings and age benefits (or no deficits) in real-world settings. We propose a theoretical account that explains this "age-PM-paradox" as a c...

Cognitive aging researchers have long reported "paradoxical" age differences in prospective memory (PM), with age deficits in laboratory settings and age benefits (or no deficits) in real-world settings. We propose a theoretical account that explains this "age-PM-paradox" as a consequence of both methodological factors and developmental changes in cognitive abilities and personality traits. To test this account, young and older adults performed a series of naturalistic PM tasks in the lab and real world. Age-related PM deficits were observed in both lab-based tasks where demands were implemented using virtual reality and in-person role-playing. In contrast, older adults performed equal to or better than young adults on both real-world tasks, where demands were implemented in participants' daily lives. Consistent with our proposed account, an index of these "paradoxical" effects was partially predicted by age-related differences in working memory, vigilance, agreeableness, and neuroticism, whose predictive utility varied across task settings.

Longevity Relevance Analysis (3)

The paper addresses cognitive aging and the paradox of age-related differences in prospective memory, which is relevant to understanding cognitive decline in older adults. However, it primarily focuses on methodological factors and individual differences rather than addressing the root causes of aging or proposing interventions for lifespan extension. The findings contribute to the field of cognitive aging but do not present significant advancements that would have a major impact on longevity research.

Sleep Duration Polygenic Risk and Phenotype: Associations with Biomarkers of Accelerated Aging in the Baltimore Longitudinal Study of Aging.

David W Sosnowski, Emily J Smail, Brion S Maher, ★ Luigi Ferrucci ... · Sleep · Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. · pubmed

We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data o...

We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data on self-reported sleep (

Longevity Relevance Analysis (3)

The paper claims that genetic risk for short sleep and self-reported short sleep are associated with biomarkers of accelerated aging. This research explores the relationship between sleep duration and biological aging, which is pertinent to understanding the mechanisms of aging and potential interventions.