Longevity Papers

Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice.

Agnieszka Zaczek, Andrzej Lewiński, Małgorzata Karbownik-Lewińska ... · Longevity · Department of Endocrinology of Ageing, Medical University of Lodz, Lodz, Poland. · pubmed

Emerging research underscores the pivotal role of adipose tissue in regulating systemic aging processes, particularly when viewed through the lens of the endocrine hypotheses of aging. This study delves into the unique adipose characteristics in an important animal model of aging...

Emerging research underscores the pivotal role of adipose tissue in regulating systemic aging processes, particularly when viewed through the lens of the endocrine hypotheses of aging. This study delves into the unique adipose characteristics in an important animal model of aging - the long-lived Ames dwarf (df/df) mice. Characterized by a Prop1

Longevity Relevance Analysis (4)

This paper investigates the role of visceral adipose tissue in the context of longevity and metabolic health, specifically using the Ames dwarf mouse model, which is known for its extended lifespan. By examining gene expression in different types of adipose tissue, the study contributes to understanding the biological mechanisms underlying aging and metabolic health, aligning with the goal of addressing root causes of aging. However, while the findings may provide solid insights, they do not appear to present groundbreaking advancements that would significantly shift the field, hence the moderate impact score.

Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging.

Hongzhou Zhang, Shuang Leng, Fei Gao ... · Vascular Stiffness · National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. · pubmed

Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted meta...

Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus. In 194 subjects (71 ± 8.6 years; 88 women), AOGLS (mean 5.6 ± 2.1%) was associated with PWV (R = -0.3644, p < 0.0001), LVGLS (R = 0.2756, p = 0.0001) and VAC (R = -0.3742, p <0.0001). Stiff aorta denoted by low AOGLS <4.26% (25

Longevity Relevance Analysis (4)

The paper investigates the relationship between aortic stiffness, fatty acid metabolism, and cardiovascular aging, which aligns with the broader themes of aging and age-related physiological changes. However, while it presents solid research, the findings appear to be incremental rather than groundbreaking, focusing on associations rather than interventions that could directly address the root causes of aging. Thus, it contributes to the understanding of cardiovascular aging but does not significantly advance the field in a transformative way.

Modulation of neural gene networks by estradiol in old rhesus macaque females.

Rita Cervera-Juanes, Kip D Zimmerman, Larry Wilhelm ... · Macaca mulatta · Department of Translational Neuroscience, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA. rcervera@wakehealth.edu. · pubmed

The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene expression and DNA methylation (DNAm) patte...

The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of E2 on the brain, we examined differential gene expression and DNA methylation (DNAm) patterns in the nonhuman primate brain following ovariectomy (Ov) and subsequent subcutaneous bioidentical E2 chronic treatment. We identified several dysregulated molecular networks, including MAPK signaling and dopaminergic synapse response, that are associated with ovariectomy and shared across two different brain areas, the occipital cortex (OC) and prefrontal cortex (PFC). The finding that hypomethylation (p = 1.6 × 10

Longevity Relevance Analysis (3)

The paper investigates the molecular effects of estradiol on the brain in the context of aging, specifically focusing on gene expression and DNA methylation changes following ovariectomy in old rhesus macaque females. While it addresses a biological mechanism related to aging, it primarily explores the effects of hormone replacement rather than directly targeting the root causes of aging or lifespan extension. The findings contribute to understanding age-related changes in the brain but do not present a significant advancement in longevity research.

Fitness age outperforms body mass index in differentiating aging patterns and health risk profiles of healthy adults aged 51-80 years.

Manca A, Ventura L, Martinez G ... · Body Mass Index · Department of Biomedical Sciences, University of Sassari, Viale S. Pietro 43/B, 07100, Sassari, Italy. · pubmed

Physical fitness has been extensively shown to strongly associate with general health status and major health risks. Here we tested the ability of a novel estimate of fitness age (FitAge) to differentiate aging trajectories.This study aimed at (1) testing the ability of FitAge to...

Physical fitness has been extensively shown to strongly associate with general health status and major health risks. Here we tested the ability of a novel estimate of fitness age (FitAge) to differentiate aging trajectories.This study aimed at (1) testing the ability of FitAge to differentiate aging patterns among decelerated, normal, and accelerated agers in selected health domains, (2) estimating the risk for developing major health issues depending on the aging trajectory, and (3) comparing FitAge to body mass index (BMI) categorization in differentiating healthy from unhealthy aging patterns.A total of 176 volunteers participated in this cross-sectional study. Participants underwent clinical screening and a comprehensive assessment of body composition, nutritional and health-related status, cognitive functioning, and haematochemical analyses with routine tests, oxidative stress, and inflammation markers. Scores for major health risks were also computed.FitAge outperformed BMI in estimating major health risk scores and was able to differentiate decelerated from normal and accelerated agers for health risk profile and several physiological domains. Body composition, immune system activation, and inflammation markers emerged as those variables flagging the largest differences between decelerated and accelerated aging patterns.The novel estimate of biological aging can accurately differentiate both in women and men decelerated from accelerated agers in almost all the domains scrutinized. Overall, decelerated aging is linked to positively oriented features which associate with reduced risk of developing major health issues.The present findings have potential relevance and practical implications to identify individuals at higher risk of accelerated aging according to their FitAge estimated via simple and cost-effective motor tests.

Longevity Relevance Analysis (4)

The paper presents a novel approach to estimating biological aging through the concept of fitness age (FitAge), which is relevant to longevity research as it seeks to differentiate aging patterns and health risk profiles in adults. By focusing on physical fitness as a determinant of health status and aging trajectories, it contributes to understanding how lifestyle factors can influence aging processes. However, while the findings are solid and provide useful insights, they do not represent a major breakthrough or transformative advancement in the field of longevity research, hence the moderate impact score.