Longevity Papers

Current Week (April 27 - May 02, 2026)
and Previous Week (April 25 - April 26, 2026)


Weekly AI-generated podcast (YT) (Apple) (feed), March 15 episode:
Friday, May 01, 2026
Matthew Lacey, Lucie Beresova, Alzbeta Srovnalova ... · GeroScience · Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic. · pubmed
Senescent cells accumulate with age and contribute to tissue dysfunction and chronic inflammation. Senolytic agents that selectively eliminate senescent cells hold therapeutic promise; however, few mechanistic classes have been established. Using Cell Painting-based morphological...
Pedro Sant' Anna Barbosa Ferreira, Stella Trompet, Eline Slagboom ... · GeroScience · Department of Biomedical Data Sciences, section of Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZA, Leiden, The Netherlands. psb.ferreira@lumc.nl. · pubmed
Aging is a major risk factor for chronic diseases. Unlike the general population, members of long-lived families maintain exceptional health as they age, with over 10 years delayed onset of their first chronic disease. We therefore hypothesize that one of the key features explain...
Xiaoxue Qiu, You Lu, Yuwei Tang ... · Hepatocytes · Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. · pubmed
Hepatocyte senescence is increasingly recognized as a pathogenic driver of metabolic dysfunction-associated steatohepatitis (MASH). Through single-nucleus transcriptomic profiling, we identified a discrete population of disease-associated hepatocytes (daHep) exhibiting enrichment...
Thursday, April 30, 2026
Kan Yu, Nengzheng Wang, Xinyi Huang ... · Enrofloxacin · State Key Laboratory of Genetics and Development of Complex Phenotypes, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, China. · pubmed
Environmental antibiotic pollution is an underexplored contributor to gut aging and chronic intestinal diseases. We provide evidence that chronic exposure to enrofloxacin (ENR), a commonly detected veterinary antibiotic, accelerates gut aging and disease progression through a mit...
Oleksandra Soldatkina, Laura Ventura-San Pedro, Natàlia Pujol-Gualdo ... · Nature aging · Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain. · pubmed
Female reproductive aging has systemic health implications, yet tissue-level dynamics remain poorly understood. Here we integrate deep learning analysis of 1,112 histology images with RNA sequencing from 659 samples across seven female reproductive organs in donors aged 20-70 yea...
Tuesday, April 28, 2026
Eric K F Donahue, Kristopher Burkewitz · Autophagy · Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. · pubmed
Age-associated changes in organelle structure are often viewed as passive deterioration. Our recent work challenges this view by identifying an evolutionarily conserved, age-onset remodeling of the endoplasmic reticulum (ER) that is actively driven by ER-phagy. Across multiple ce...
Lin Shi, Yu-Long Liu, Meng-Ni Dai ... · npj aging · Jiangxi Province Key Laboratory of Aging and Disease, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, Nanchang, China. · pubmed
Aging is driven in part by progressive deterioration of proteostasis and antioxidant defense, leading to cellular dysfunction and age-associated disease. The naturally occurring methylated inositol D-pinitol (DP) was reported to present metabolic, antioxidant, and anti-inflammato...
Monday, April 27, 2026
Chaoqiang Chen, Zhidong Liu, Yanhang Sun ... · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Department of Orthopedics, The Eighth Affiliated Hospital ,Sun Yat-Sen University, Shenzhen, China. · pubmed
Senile osteoporosis (SOP) is characterized by impaired osteogenesis of bone-marrow mesenchymal stem cells (MSCs). The underlying metabolic basis remains unclear. This study aimed to identify energy-regulating pathways sustaining MSC osteogenesis during aging. Progressive activati...
Sunday, April 26, 2026
Shalini Dimri-Wagh, Swarnabh Bhattacharya, Gharam Yassen ... · Nature communications · Department of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa, Israel. yashree.dimri@gmail.com. · pubmed
Recent studies report that epithelial differentiated cells can undergo a reverse process called dedifferentiation in response to stem cell loss. However, the extent of this reversion and the plasticity of young versus aged-differentiated cells remain unclear. Here we show that de...
Ioanna Skampardoni, Guray Erus, Ilya M Nasrallah ... · Nature communications · AI2D Center for AI and Data Science for Integrated Diagnostics, University of Pennsylvania, Philadelphia, PA, USA. · pubmed
Machine learning can unravel heterogeneous patterns of brain aging and neurodegeneration, but existing methods offer limited insights into disease progression due to reliance on cross-sectional data. We introduce Coupled Cross-sectional and Longitudinal Non-negative Matrix Factor...
Saturday, April 25, 2026
Yaoli Hou, Zhiying Zeng, Sheng He ... · The journals of gerontology. Series A, Biological sciences and medical sciences · Department of Medical Administration, the Second Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China. · pubmed
Immunosenescence-the age-related decline of immune function-drives a state of chronic, sterile inflammation termed inflammaging. Far from passive deterioration, this process is actively orchestrated by distinct but interconnected hallmarks: erosion of lymphoid organs, myeloid-bia...
Meng Ma, Juan Long, Yuting Chen ... · Gene Regulatory Networks · Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. · pubmed
Complex phenotypes, including aging, are influenced by a connected gene regulatory network with many interacting nodes. It has been proposed that some genes, termed "core genes," directly contribute to a trait, whereas "peripheral genes" influence the trait indirectly through net...
Yanzhuo Kong, Damola Adejoro, Christopher Winefield ... · Saccharomyces cerevisiae · College of Food and Chemical Engineering, Shaoyang University, Shaoyang, China. · pubmed
Aging is commonly viewed as a passive consequence of accumulated damage; however, emerging evidence suggests that it may also represent an adaptive response to environmental stress. Here, we combined transcriptomic and metabolomic profiling of Saccharomyces cerevisiae to investig...
Masaki Ohyagi, Minako Ito, Akihiko Yoshimura · Inflammation and regeneration · Division of Molecular Pathology, Research Institute for Biomedical Sciences, Tokyo University of Science, 2669 Yamazaki, Noda-City, Chiba, 278-0022, Japan. ohyanuro@gmail.com. · pubmed
Senescence of T cells is strongly linked to organismal aging through two interconnected processes: chronic low-grade inflammation and reduced immune surveillance of senescent cells. T cells are particularly vulnerable to thymic involution, hematopoietic stem cell aging, repeated ...